Quinine, an old anti-malarial drug in a modernworld: role in the treatment of malaria. It was proved that higher lipophilicity could increase pharmacology activityĪchan, J., Talisuna, A.O., Erhart, A., Yeka, A., Tibenderana, J.K., Baliraine, F.N., Rosen-thal, P.J., D’Alessandro, U., 2011. BSLT result showed that cinchonidine isobutyrate ester had LC 50 value of 75.16 ppm which was more toxic than cinchonidine that had LC 50 value of 99.2 ppm. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Higher lipophilicity makes it easier for the compund to pass through cell membrane. Synthesized ester was aimed to gain higher lipophilicity. Cinchonidine is predicted to have anticancer activity. Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT).
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